CPLC Research

Theme 1: Single-molecule biophysics at the molecular-cellular interface

Theme 1


Highlights from this project:

Description: Single-molecule biophysics at the molecular-cellular interface leverages our newly developed single-molecule techniques to control and measure quantitatively and sensitively single-molecule forces from living cells and sub-cellular assemblies, measure DNA physical properties genome-wide and correlate them to molecular behavior and physiological consequences, and probe protein-nucleic acid interactions at the proteomic/cellular level.

Theme 2: Resolving cellular processes with single-cell experiments

Theme 2


Highlights from this project:

Description: Maximizing information content of single cell experiments focuses on processes in living cells as they unfold in real time. We develop next-generation RNA imaging technology to probe the many functions of RNA. Evolution in the laboratory is quantified through highthroughput microscopy in real time. Single-cell measurements probe how bacteria respond to environmental stimuli.

Theme 3: Collective dynamics: from cell-cell interaction to multicellular systems

Theme 3











Highlights from this project:

Description: Collective dynamics: from cell-cell interaction to multicellular organisms builds on our expertise in single-molecule and single-cell probes extending research to complex systems ranging from cell-cell interactions between neurons, to communication among bacterial cells, all the way to the behavior of multicellular organisms.

Theme 4: Increasing biological realism in theory and computation

Theme 4




Highlights from this project:

Description: Increasing biological realism in theory and computation exploits recent methodological advances, many our own, to extend computational and theoretical biophysics to the very small (electronic) and very large (whole-cell) scales. In bottom-up and top-down approaches we explore computationally, jointly with experiment, such systems as bioenergetics organelles, chromatin, signaling networks as well as whole cells.