Postdoctoral Fellow or Research Scientist - University of Iowa

1/15/2019 4:56:04 PM CPLC Staff

University of Iowa is looking for motivated researchers to carry out projects that will provide a greater understanding of the coordinated and dynamic nucleoprotein transactions critical for high fidelity DNA repair and replication. The goal is to dissect the mechanisms that funnel “normal” DNA repair intermediates into “rogue” processes that destabilize the genome and lead to cancer, cell death and/or emergence of chemotherapeutic resistance, and to be able to manipulate these processes in development of new cancer therapies. The projects range from biochemical reconstitutions of DNA recombination, repair and replication reactions and structural and single-molecule analyses of the proteins and enzymes coordinating these reactions, to development of new single-molecule technologies and combined HTS/CADD campaigns that identify scaffolds that can be developed into potent inhibitors of human DNA repair proteins.

The ideal fit for the aforesaid position is a postdoctoral researcher with a background in single-molecule biophysics, structural biology, molecular biology or biochemistry of protein-nucleic acid interactions and a desire to extend their expertise in these areas, and/or to branch into drug discovery.

University of Iowa, Carver College of Medicine provide ample opportunities for cutting edge, interdisciplinary and collaborative research. It is an excellent environment for postdoctoral studies. Iowa City is also a delightful town to live in. It is consistently ranked among the best college towns to live in US, is a home to the internationally recognized writers’ workshop, IDT and is quite affordable.

Interested candidates can contact

Maria Spies, PhD

Professor of Biochemistry and Radiation Oncology
Carver College of Medicine
University of Iowa
51 Newton Rd., 4-532 BSB
Iowa City, IA 52242


Phone: +1-319-335-3221
Lab Phone: +1-319-335-3223
Fax: +1-319-335-9570

Another postdoctoral position is available with Dr. Ashley Spies.

His research group focuses on innovative approaches to structure-based drug discovery, employing advanced molecular dynamics simulations as well as experimental biophysical methods such as SPR and X-ray crystallography to further the understanding of complex protein-ligand interactions.They are seeking a postdoctoral researcher with a background in X-ray crystallography and/or expertise in SPR, NMR or ITC, who would like to work at the interface between computational and experimental biophysical chemistry.

In late 2019 the M A Spies group is moving into a new state-of-the art Pharmacy building, which will house the Medicinal and Natural Products Chemistry division:

Interested candidates should contact Professor M. Ashley Spies at