Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site


Cyclophilin A (CypA) is a host cell factor that is important in multiple pathways during an infection, including inflammation, immunity, and protein trafficking. Improper regulation of CypA plays a role in facilitating cancer, autoimmune disease, and HIV infections. Klaus Schulten, Peijun Zhang, and co-authors used a multidisciplinary approach to discover an interaction between CypA and the HIV-1 capsid protein. By resolving an 8-Å cryoEM structure and utilizing all-atom molecular dynamics and solid-state NMR, the authors unexpectedly reveal a novel capsid binding site on CypA. A single molecule of CypA is now known to bind two subunits of the HIV-1 capsid, resulting in increased capsid stabilization. Identification of this new binding site reveals the possibility for new HIV therapeutics that could target this unique interaction.

More information can be found in the complete Nature Communications article: or in this recent news article:

1/16/2014 Lance Cooper

This semester Kat Kolumban will be the teaching assistant for the Special English Class, a conversational English class that is offered on campus for international students, their family members, and members of the community. In the class students will practice English for daily life activities like eating in a restaurant, going to the doctor, going shopping, etc.

If students are interested in taking the class, they need to sign up for a placement interview. Students can go to to get more information about the class and to sign up for the interview. Any way that you could pass this information to your international students and their families would be greatly appreciated. Please email Kat Kolumban ( for additional information.