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CPLC/iPoLS Seminar: Catherine Ann Royer, Rensselaer Polytechnic Institute "Molecular mechanisms of size control in budding yeast"

10/30/2018 10:49:45 AM

The fundamental question of how a cell knows it has grown large enough to divide has remained unanswered for decades. The balance between growth and division underlies cellular homeostasis and fitness of unicellular organisms. It defines the size of organs in higher eukaryotes and is strongly deregulated in many disease states, most notably cancer. Despite its importance and a wealth of genetic studies in budding yeast defining factors implicated in size control, the underlying molecular mechanisms have remained a mystery. To begin to define these mechanisms we have used a combination of yeast genetics, advanced single molecule and fluctuation microscopy approaches, as well as mathematical modeling. We have discovered an underlying biochemical titration of the G1/S promoter target sites by the G1/S transcriptional activators. Moreover we show that these activators are upregulated in poor nutrients, providing a molecular explanation for nutrient control of cell size.

1/7/2014 Washington University in St. Louis

Washington University in St. Louis is now accepting applications for its Research Experiences for Undergraduates (REU) Summer Program.  The REU program is an 11-week summer program geared to give undergraduates a taste of research with the hope that they will pursue graduate studies in computer science.

Our 2014 program includes several exciting opportunities including:

  • A 4-Day morning Boot Camp, giving students the computing skills needed for their specific research projects
  • The “Meet the Faculty” Lunch Series
  • A Research Skills Seminar, to help prepare students to apply to and succeed in graduate school
  • A final Research Symposium, to present their work to faculty and peers at the end of the summer.


The program is open to all US citizens and residents who have a strong background in computer science. We encourage all students with an interest in computer science (majors, minors, educated hobbyists) to apply. If you have further questions about eligibility, please first check our FAQ (http://reu.cse.wustl.edu/reu/FAQ.html) and then feel free to email reu@cse.wustl.edu.

The application deadline for the program is February 7, 2014. More information and application materials can be found at:  http://reu.cse.wustl.edu